Publications by authors named "H Persson"
Correction: Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome.
Arthritis Res Ther
December 2024
Purpose: The aim was to longitudinally explore changes in fatigue- and cognition-related symptoms during the first year after hospital treatment for COVID-19.
Method: Patients hospitalized for COVID-19 in Gothenburg, Sweden, were consecutively included from 01-07-2020 to 28-02-2021. Patients were assessed at the hospital (acute) and at 3 and 12 months after hospital discharge.
A bispecific CD40 agonistic antibody allowing for antibody-peptide conjugate formation to enable cancer-specific peptide delivery, resulting in improved T proliferation and anti-tumor immunity in mice.
Nat Commun
November 2024
Current antibody-based immunotherapy depends on tumor antigen shedding for proper T cell priming. Here we select a novel human CD40 agonistic drug candidate and generate a bispecific antibody, herein named BiA9*2_HF, that allows for rapid antibody-peptide conjugate formation. The format is designed to facilitate peptide antigen delivery to CD40 expressing cells combined with simultaneous CD40 agonistic activity.
View Article and Find Full Text PDFCharacteristics of gene expression in epicardial adipose tissue and subcutaneous adipose tissue in patients at risk for heart failure undergoing coronary artery bypass grafting.
BMC Genomics
October 2024
Article Synopsis
- - The study investigates the differences in gene expression between epicardial adipose tissue (EAT) around the heart and subcutaneous adipose tissue (SAT) in patients undergoing heart surgery, revealing distinct gene clusters linked to heart failure (HF) characteristics.
- - Researchers identified 17 gene clusters in EAT, with seven showing significant correlations to heart failure measures, indicating a unique role that EAT may play in heart dysfunction, especially related to inflammation and tissue repair.
- - The findings emphasize the different impacts of EAT and SAT on heart health, suggesting that EAT could influence the progression of heart failure, which necessitates further studies to better understand these connections.
Article Synopsis
- - This study tracked symptoms of depression, anxiety, post-traumatic stress disorder, and fatigue in 211 patients over a year after being hospitalized for COVID-19.
- - After 3 months, some improvements in fatigue were noted, but overall mental health indicators remained concerning at the 12-month mark, with many still experiencing anxiety, depression, or PTSD symptoms.
- - The findings suggest that most patients did not achieve full mental health recovery a year post-hospitalization, highlighting the need for ongoing mental health support.