Publications by authors named "H Peluffo"
Article Synopsis
- Emerging research indicates that immune receptors, like CD300f, may play vital roles in processes linked to aging, such as metabolism, inflammation, and cognitive decline.
- CD300f is a unique immune receptor that balances activating and inhibitory signals, impacting inflammation and brain health.
- Studies on CD300f knockout mice showed reduced lifespan and healthspan, along with signs of inflammation, cognitive decline, and altered metabolic processes, highlighting its importance for healthy aging.
Article Synopsis
- Emerging evidence indicates that immune receptors like CD300f play a key role in microglial and macrophage functions, influencing inflammation and neuronal survival.
- CD300f acts as a modulator for inflammation and efferocytosis, showing neuroprotective effects post-brain injury through its interactions with neurons.
- Experimental results demonstrate that blocking CD300f leads to increased neuronal death and a potentially neurotoxic environment, while the addition of GDNF can mitigate this effect.
Activating and inhibitory immune receptors play a critical role in regulating systemic and central nervous system (CNS) immune and inflammatory processes. The CD200R1 immunoreceptor induces a restraining signal modulating inflammation and phagocytosis in the CNS under different inflammatory conditions. However, it remains unknown whether CD200R1 has a role in modulating the inflammatory response after a peripheral nerve injury, an essential component of the successful regeneration.
View Article and Find Full Text PDFSex-dependent role of CD300f immune receptor in generalized anxiety disorder.
Brain Behav Immun Health
February 2021
Article Synopsis
- Generalized Anxiety Disorder (GAD) is common and linked to immune system changes, with CD300f immune receptors found to affect synapse remodeling and immune responses.
- Research using CD300f knockout mice showed that male mice without this receptor exhibited lower anxiety behaviors in several tests.
- A study involving 1111 individuals found that a specific genetic variation in the CD300f gene offered protection against GAD in men, highlighting the need to understand sex-based differences in anxiety and potential treatments.
A role for microglia in neuropsychiatric diseases, including major depressive disorder (MDD), has been postulated. Regulation of microglial phenotype by immune receptors has become a central topic in many neurological conditions. We explored preclinical and clinical evidence for the role of the CD300f immune receptor in the fine regulation of microglial phenotype and its contribution to MDD.
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