Prognostic significance of matrix metalloproteinases 2 and 9 in bladder cancer.

Background: The levels of matrix metalloproteinases MMP-2 and MMP-9 (type IV collagenases), which degrade the extracellular matrix of the basement membrane, were evaluated as prognostic indicators of metastasis in urothelial carcinoma.

Materials And Methods: Quantitative gel zymography and immunohistochemistry were used and compared with clinical data at the follow-up period of 36 months.

Results: Zymographical analysis of the levels of MMP-9 and active MMP-2 showed a statistically significant increase with tumor grade and invasiveness.