Publications by authors named "H Padilla-Nash"
Article Synopsis
- * This study focuses on seven newly characterized cell lines from type 1 pRCC, including one from a hereditary papillary renal carcinoma (HPRC), highlighting genetic changes such as chromosome gains and MET mutations that are relevant to tumor behavior.
- * The established cell lines are significant for in vivo research, as they can help understand the disease's biology and serve as models for testing new therapies targeted at type 1 pRCC.
The evolution of single cell-derived colorectal cancer cell lines is dominated by the continued selection of tumor-specific genomic imbalances, despite random chromosomal instability.
Carcinogenesis
July 2018
Article Synopsis
- Researchers studied different types of colorectal cancer cells to see how their chromosomes change and why this matters for treatment.
- They found that some cell lines had stable chromosomes, while others were unstable and mixed up.
- By looking closely at how these cells grow and change over time, they discovered that certain cells keep changing, while others stay more consistent, which helps them understand how cancer develops.
Epigenetic regulation of chromatin states is thought to control gene expression programs during lineage specification. However, the roles of repressive histone modifications, such as trimethylated histone lysine 20 (H4K20me3), in development and genome stability are largely unknown. Here, we show that depletion of SET and MYND domain-containing protein 5 (SMYD5), which mediates H4K20me3, leads to genome-wide decreases in H4K20me3 and H3K9me3 levels and derepression of endogenous LTR- and LINE-repetitive DNA elements during differentiation of mouse embryonic stem cells.
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- * Researchers developed a new cell line, UOK276, from a large ChRCC tumor that shows sarcomatoid differentiation, providing a model to study tumor biology and treatment responses.
- * UOK276 displays unique genetic characteristics, including a hyperdiploid state and a TP53 mutation, and has shown responsiveness to a therapeutic agent, making it valuable for exploring treatments for aggressive ChRCC.
Human colorectal carcinomas are defined by a nonrandom distribution of genomic imbalances that are characteristic for this disease. Often, these imbalances affect entire chromosomes. Understanding the role of these aneuploidies for carcinogenesis is of utmost importance.
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