Publications by authors named "H P Sinn"
Objective: To assess the feasibility, acceptability, and efficacy of a 12-week in-person Creative Arts Therapy intervention in reducing psychological distress and burnout symptoms in non-patient-facing healthcare workers.
Background: Burnout and psychological distress among non-patient-facing healthcare workers are significant and understudied problems in healthcare systems.
Methods: Non-patient-facing healthcare workers with burnout symptoms were randomly assigned to one of four Creative Arts Therapy modalities (art, music, creative writing, or dance/movement) or a control group.
Therapy-induced molecular adaptation of triple-negative breast cancer is crucial for immunotherapy response and resistance. We analyze tumor biopsies from three different time points in the randomized neoadjuvant GeparNuevo trial (NCT02685059), evaluating the combination of durvalumab with chemotherapy, for longitudinal alterations of gene expression. Durvalumab induces an activation of immune and stromal gene expression as well as a reduction of proliferation-related gene expression.
View Article and Find Full Text PDFArticle Synopsis
- X-ray free-electron lasers (XFELs) allow for novel experiments that traditional X-ray laser facilities cannot support, with more XFEL facilities being developed for greater pulse energies and brilliance.
- An important aspect of increasing pulse power is understanding the maximum pulse fluence that grazing-incidence FEL mirrors can handle.
- The study focuses on comparing the damage resistance of boron carbide (BC) coatings to polished silicon under soft X-ray FEL pulses, aiming to identify the potential benefits and limitations of using BC coatings in X-ray mirrors.
The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie (German Gynecological Oncology Group, AGO) presents the 2024 update of the evidence-based recommendations for the diagnosis and treatment of patients with locally advanced and metastatic breast cancer.
View Article and Find Full Text PDFIntroduction: Each year the interdisciplinary AGO (Arbeitsgemeinschaft Gynäkologische Onkologie, German Gynecological Oncology Group) Breast Committee on Diagnosis and Treatment of Breast Cancer provides updated state-of-the-art recommendations for early and metastatic breast cancer.
Methods: The updated evidence-based treatment recommendations for early and metastatic breast cancer have been released in March 2024.
Results And Conclusion: This paper concisely captures the updated recommendations for early breast cancer chapter by chapter.