Publications by authors named "H P Sarma"
Article Synopsis
- Carbon quantum dots (CQDs) are flexible nanomaterials used in various applications like diagnostics, sensing, bioimaging, and drug delivery, thanks to their tunable chemical properties.
- This study synthesized lactic acid-derived nitrogen doped CQDs (LAdN-CQDs) and found they can inhibit the formation of toxic fibrils from hen egg-white lysozyme (HEWL) in a dose-dependent manner, achieving up to 50% inhibition.
- LAdN-CQDs showed biocompatibility in neuroblastoma cells by maintaining mitochondrial function and reducing reactive oxygen species, suggesting they may have neuroprotective properties and could be a green chemistry solution in healthcare.
Aging is an inevitable biological process, and emerging research has highlighted the potential of dietary and pharmacological interventions to decelerate the trajectory of age-related diseases and prolong the health span. This study evaluates the protective effects of Musa balbisiana seed on healthy aging using D-galactose-induced accelerated aging rats. The results suggested that the bioactive ethyl acetate fraction of Musa balbisiana seed extract (BF) exhibited protective effects against aging-induced oxidative stress by reducing oxidative DNA damage, advanced glycation end-product formation, and malondialdehyde levels while restoring antioxidant and glyoxalase enzyme activities.
View Article and Find Full Text PDFUnderwater superoleophobic and magnetic hydrogel for cascade chemical reactions.
Chem Commun (Camb)
November 2024
Magnetic hydrogels often suffer from low saturation magnetization and poor chemical and mechanical tolerance. Herein, we report magnetic nanoparticles ( FeO) grown in an interpenetrating network containing both physical and covalent crosslinkages, which allowed the development of a high-water-content (∼95 wt%) and chemically ( stable at extreme pH values of 1 and 12) and mechanically (Young's modulus of 550 kPa) stable magnetic hydrogel with high saturation magnetization (85 emu g). Moreover, the inherent high water content endowed the magnetic hydrogel with underwater superoleophobicity (OCA 160°), which enabled no-loss transport and mixing of liquid droplets as well as a cascade droplet (microliters) chemical reaction underwater through on-demand application of external magnetic field.
View Article and Find Full Text PDFPotential probiotic Lactiplantibacillus plantarum strains alleviate TNF-α by regulating ADAM17 protein and ameliorate gut integrity through tight junction protein expression in in vitro model.
Cell Commun Signal
October 2024
Article Synopsis
- Lactiplantibacillus species, particularly strains MKMB01 and MKMB02, show promise as probiotics that help regulate the immune response against enteric pathogens like Salmonella enterica typhimurium.
- The study utilized various cell lines and techniques, including qRT-PCR and electron microscopy, to assess the probiotics' effects on immune responses and gut integrity.
- Results indicated that both strains enhanced gut health and reduced inflammation by maintaining tight junction proteins and downregulating pro-inflammatory cytokines, while also improving mitochondrial function impaired by Salmonella.
Objective: The study aimed at designing a pH sensitive Lipid polymeric Hybrid nanoparticle (LPHNP) for targeted release of Paclitaxel (PTX) and Curcumin (CUR) in breast cancer.
Significance: Such systems shall result in controlled triggered release in acidic microenvironment of tumor cells with improved pharmacokinetic profile.
Methods: Chitosan-coated CUR and PTX coloaded pH-sensitive LPHNPs were synthesized employing nanoprecipitation technique.