Publications by authors named "H P Makarenkova"
Article Synopsis
- Fibrosis, especially idiopathic pulmonary fibrosis (IPF), is linked to abnormal healing processes in the lungs that can lead to organ failure, with no current cure.
- The study investigates activated myofibroblasts (aMYFs), their different subtypes, and their roles in lung repair and damage using genetic and transcriptomic analysis in mice, as well as human data.
- Findings reveal that aMYFs can be categorized into four distinct groups, with a specific subset linked to both the progression and resolution of fibrosis, suggesting new potential treatment targets for managing IPF.
Myoepithelial cells (MECs) are a unique subset of epithelial cells that possess several smooth muscle cell characteristics, such as a high number of actin-myosin filaments and the ability to contract. These cells are primarily located around the secretory cells of exocrine glands, including the salivary, mammary, lacrimal, and sweat glands. Their primary functions involve the construction of the basement membrane and help with secretion of gland products through contraction.
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- * Researchers cultured MECs from mice and treated them with gDNA, measuring cytokine secretion and inflammasome activation through various assays, including ELISA and immunofluorescence microscopy.
- * Results showed that gDNA activated AIM2 inflammasome and STING pathways in MECs, leading to the secretion of pro-inflammatory cytokines IL-1β and IL-18, suggesting a significant role for self-gDNA in
Aging is a complex biological process that is characterized by low-grade inflammation, called inflammaging. Aging affects multiple organs including eye and lacrimal gland. Tumor necrosis factor (TNF) is a pleiotropic cytokine that participates in inflammation, activation of proteases such as cathepsin S, and formation of ectopic lymphoid organs.
View Article and Find Full Text PDFThe lacrimal gland (LG) secretes aqueous tears. Previous studies have provided insights into the cell lineage relationships during tissue morphogenesis. However, little is known about the cell types composing the adult LG and their progenitors.
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