Publications by authors named "H P Kubis"
Upregulation of GRP78 is accompanied by decreased antioxidant response and mitophagy promotion in streptozotocin-induced type 1 diabetes in rats.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- Endoplasmic reticulum stress, oxidative stress, and mitochondrial dysfunction are linked processes that contribute to the development of diabetes mellitus, as shown in a study using two models: β-TC-6 cell line and rat models of type 1 diabetes.
- The study found that both models exhibit an increase in the GRP78 protein, which is associated with a stressed cellular environment, while also showing a breakdown in antioxidant systems and reduced ATP levels in pancreatic cells.
- The findings suggest that GRP78 upregulation under glucotoxic conditions leads to antioxidant depletion and promotes mitophagy, indicating that GRP78 might be a promising target for diabetes treatment.
Background/objectives: Respiratory muscle training (RMT) was recognized as an effective means to improve respiratory muscle (RM) strength and enhance exercise performance. The purpose of this study was to examine the effect of low-intensity RMT on RM strength, pulmonary function, and performance.
Methods: Fourteen healthy active adults were assigned randomly to either a training or placebo group.
Introduction: Hamstring strain injuries (HSI) and re-injuries are endemic in high-speed running sports. The biceps femoris long head (BFlh) is the most frequently injured muscle among the hamstrings. Structural parameters of the hamstring muscle are stated to be susceptible to strain injuries at this location.
View Article and Find Full Text PDFWomen's experiences of social support during pregnancy: a qualitative systematic review.
BMC Pregnancy Childbirth
November 2023
Background: Social support during pregnancy can alleviate emotional and physical pressures, improving the well-being of mother and child. Understanding women's lived experiences and perceptions of social support during pregnancy is imperative to better support women. This systematic review explores and synthesises the qualitative research on women's experiences of social support during pregnancy.
View Article and Find Full Text PDFMotor imagery training could be an important treatment of reduced muscle function in patients and injured athletes. In this study, we investigated the efficacy of imagery training on maximal force production in a larger muscle group (hip abductors) and potential bilateral transfer effects. Healthy participants ( = 77) took part in two experimental studies using two imagery protocols (∼30 min/day, 5 days/week for 2 weeks) compared either with no practice (study 1), or with isometric exercise training (study 2).
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