Enhancer-driven Shh signaling promotes glia-to-mesenchyme transition during bone repair.

Plp1-lineage Schwann cells (SCs) of peripheral nerve play a critical role in vascular remodeling and osteogenic differentiation during the early stage of bone healing, and the abnormal plasticity of SCs would jeopardize the bone regeneration. However, how Plp1-lineage cells respond to injury and initiate the vascularized osteogenesis remains incompletely understood. Here, by employing single-cell transcriptional profiling combined with lineage-specific tracing models, we uncover that Plp1-lineage cells undergoing injury-induced glia-to-MSCs transition contributed to osteogenesis and revascularization in the initial stage of bone injury.

Sperm DNA fragmentation index: limited effectiveness on predicting embryo quality in assisted reproduction technology treatments.

Purpose: Prior sperm DNA fragmentation index (DFI) thresholds for diagnosing male infertility and predicting assisted reproduction technology (ART) outcomes fluctuated between 15 and 30%, with no agreed standard. This study aimed to evaluate the impact of the sperm DFI on early embryonic development during ART treatments and establish appropriate DFI cut-off values.

Methods: Retrospectively analyzed 913 couple's ART cycles from 2021 to 2022, encompassing 1,476 IVF and 295 ICSI cycles, following strict criteria.

Poly(3,4-ethylenedioxithiophene) coated on vanadium oxide hydration nanobelts enhancing ammonium-ion storage for hybrid supercapacitors.

The development of electrode materials for aqueous ammonium-ion supercapacitors (NH-SCs) has garnered significant attention in recent years. Poor intrinsic conductivity, sluggish electron transfer and ion diffusion kinetics, as well as structural degradation of vanadium oxides during the electrochemical process, pose significant challenges for their efficient ammonium-ion storage. In this work, to address the above issues, the core-shell VO·nHO@poly(3,4-ethylenedioxithiophene) composite (denoted as VOH@PEDOT) is designed and prepared by a simple agitation method to boost the ammonium-ion storage of VO·nHO (VOH).

Cross-Sectional Study Gender Pay Gap in Industry General Payments to U.S. General and Fellowship-Trained Surgeons.

Introduction: Gender disparities exist in nonresearch industry payments to U.S. physicians, but detailed analyses specific to surgeons are limited.