Publications by authors named "H P Bowditch"
Left Ventricular Outflow Tract (LVOT) obstruction occurs in approximately 70% of Hypertrophic Cardiomyopathy (HCM) patients and currently requires imaging or invasive testing for diagnosis, sometimes in conjunction with provocative physiological or pharmaceutical stimuli. To identify potential biomarkers of LVOT obstruction, we performed proteomics profiling of 1305 plasma proteins in 12 HCM patients with documented LVOT obstruction, referred for surgical myectomy. Plasma was collected at the surgical preoperative visit, approximately one month prior to surgery and then at the post-surgical visit, approximately 3 months later.
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- Transverse aortic constriction (TAC) is a mouse model used to study heart issues caused by increased pressure, and the severity of the constriction is determined by the size of the needle used during surgery.* -
- In a study, adult male mice underwent TAC surgery with different needle gauges (25G, 26G, 27G) to assess how varying levels of constriction affected heart health over four weeks compared to control mice.* -
- Results showed that tighter constriction (27G) led to more serious heart problems, including heart failure symptoms and kidney atrophy, while different constriction levels resulted in distinct cardiac responses, suggesting they could be useful in various research scenarios.*
M13 and other members of the Ff class of filamentous bacteriophages have been extensively employed in myriad applications. The Ph.D.
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