[Initial experiences with the calcium antagonist tiapamil in the treatment of arterial hypertension].

24 hypertensive patients were treated with 300-450 mg tiapamil daily for 2-6 months. The antihypertensive effect of this new calcium entry blocking agent was expressed by a reduction even of extremely elevated blood pressures to the normotensive, but not to the hypotensive range, in 20 patients. The drug was well tolerated.

Pyrogen fever in rabbits pretreated with p-chlorophenylalanine or 5, 6-dihydroxytryptamine.

The hyperthermic effect of a bacterial pyrogen has been studied in rabbits pretreated or not with p-chlorophenylalanine or 5, 6-dihydroxytryptamine. The results obtained indicate that a selective reduction of cerebral 5-hydroxytryptamine levels by these drugs do not significantly affect pyrogen hypertermia.