Antimalarial Efficacy and Safety of (L.) Link Root Extract in -Infected BALB/c Mice.

Background: Emergence of resistance to antimalarial drugs presents a major drawback in efforts to control malaria. To address this problem, there is an urgent and continuous need for the development of new and effective antimalarial agents. (L.

Senna occidentalis (L.) Link root extract inhibits Plasmodium growth in vitro and in mice.

Background: Senna occidentalis (L.) Link has been used worldwide in traditional treatment of many diseases and conditions including snakebite. In Kenya, a decoction from the plant roots taken orally, is used as a cure for malaria.

Acquired Clinical Immunity to Malaria in Nonhuman Primates Coinfected with and Parasites.

Naturally acquired immunity to malaria develops over several years and can be compromised by concomitant infections. This study explored the influence of chronic schistosomiasis on clinical outcome and immunity to repeated malaria infection. Two groups of baboons ( = 8 each), were infected with Schistosoma mansoni cercariae to establish chronic infections.

Mice Pups Breastfed by Foster Mothers Whose Breast Milk Contains Plasmodium falciparum Recombinant SE36 Antigen Develop Specific Antibodies.

Intranasal instillation of SE36, a malaria vaccine candidate antigen, in lactating BALB/c strain (derived from the Bagg and albino laboratory inbred mice) female mice resulted in the appearance of the antigen in breast milk as demonstrated by sandwich ELISA and Western blot. Pups born of immunologically naive mice and breastfed on lactating foster mothers exposed intranasally to SE36 developed IgG anti-SE36 antibodies. These data demonstrate that maternal immunization in mice by this route in lactating mothers can result in active immunization of offspring via ingestion of breast milk containing antigen.