Publications by authors named "H Oki"
Purpose: Therapies for treatment of rheumatoid arthritis (RA) have shown significant improvement since the introduction of biological agents (BIO) in 2003 and Janus kinase inhibitors (JAKi) in 2013 in Japan. The rate of orthopedic surgery, including total hip arthroplasties (THA), may reflect trends in disease severity, management, and health outcomes.
Materials And Methods: An analysis of data on THAs performed at our institutes for treatment of RA with BIO or non-BIO therapy from 2004 to 2021 was conducted.
Article Synopsis
- Researchers developed a strategy to create and select triple-helical peptides that can interact with specific bioactive proteins, specifically using a yeast-based library.
- The selection process utilized a two-hybrid system to identify peptides that bind to the pigment epithelium-derived factor (PEDF), which is known for its anti-angiogenic and neurotrophic properties.
- The study revealed new binding sequences with strong affinities for PEDF, including a variant that differed from previously known collagen motifs, showcasing the potential of the library approach to discover more effective peptides.
Article Synopsis
- Early diagnosis is crucial for treating invasive fungal infections, which are challenging to identify especially from sterile abscess biopsies.
- A case study on a 65-year-old Japanese male with acute myeloid leukemia showed that despite antifungal prophylaxis, no fungi were detected in blood cultures, but fragmented fungi were found in a liver biopsy and spleen abscess.
- Retrospective analyses and deep sequencing of the fungal genome allowed identification of the causative fungus, confirmed through hybridization with a DNA probe.
Article Synopsis
- Current treatments for major depressive disorder struggle with low success rates and complications from symptoms like psychosis, while serotonin neurotransmission is an important focus for new drug targets.
- This study investigates DSP-6745, a new serotonin modulator, and its effects on depression and related symptoms.
- Results show that DSP-6745 acts as a potent serotonin transporter inhibitor and enhances neurotransmitter release, leading to rapid antidepressant-like effects and improvements in anxiety and cognitive function in animal tests.*