Publications by authors named "H Ohtsubo"
Article Synopsis
- A 78-year-old man experienced fatigue, loss of appetite, double vision, and trouble walking, which led to investigations revealing issues with his pituitary gland.
- MRI scans showed an enlarged pituitary stalk and gland, while PET-CT indicated abnormal uptake in the pituitary and nearby lymph nodes.
- The diagnosis pointed towards IgG4-associated hypophysitis, which significantly improved after steroid treatment, highlighting the importance of recognizing this condition in older patients who may have various health issues.
Objectives: We aimed to evaluate the effects of age on clinical characteristics and outcomes in biologic or targeted synthetic disease-modifying antirheumatic drug (b/tsDMARD)-naïve patients with rheumatoid arthritis (RA).
Methods: We analysed the cases of 234 Japanese b/tsDMARD-naïve RA patients who underwent b/tsDMARD treatment in a multicentre ultrasound prospective observational cohort. We compared the clinical characteristics at baseline and outcomes at 12 months between those aged ≥60 years and those <60 years.
A juvenile rough-toothed dolphin (Steno bredanensis) was live-stranded and rescued in Kanagawa Prefecture, Japan. From the results of diagnostic examinations, blood tests indicated that the dolphin was malnourished, dehydrated, and anemic. The dolphin died on sixth day of rescue despite treatment.
View Article and Find Full Text PDFCedar pollen is known as a typical allergen that causes various allergic symptoms in the nasal mucosa, conjunctiva, and skin. However, inflammation of the vulvar mucosa due to sensitization to cedar pollen is not well-known. We experienced two cases in which the detection of cedar pollen during microscopic urine sediment examination led to the diagnosis of allergic vulvovaginitis caused by cedar pollen.
View Article and Find Full Text PDFArticle Synopsis
- Glucocorticoids can effectively treat rheumatoid arthritis (RA) when used at low doses, but their impact on subsequent treatments with biologic and targeted synthetic drugs (b/tsDMARDs) needs evaluation.
- In a study of 307 RA patients, 160 were on glucocorticoids; those treated with these medications showed higher disease activity and less effective treatment responses after 12 months compared to those who were not.
- The findings suggest that patients requiring glucocorticoids may be in poorer health, which could explain their diminished response to b/tsDMARDs, highlighting the need to carefully consider glucocorticoid use during RA treatment.