Portrait of a Cerebral Killer.

: Primary amebic meningoencephalitis (PAM) caused by is a rare and devastating infection of the central nervous system, often diagnosed late, due to its rapid progression and nonspecific symptoms. We report one of the youngest documented pediatric Vietnamese cases of PAM in a 10-month-old girl from the Mekong Delta, Vietnam. The diagnosis was confirmed through multiplex real-time PCR (MPL-rPCR), microscopy, and sequencing.

Conjugation of Triterpenic Acids with 3-Aminoquinuclidine Moiety: An Approach to Acetylcholinesterase Mixed or Uncompetitive Type Inhibitors.

Alzheimer's disease (AD) poses a significant public health issue. Despite the fact that today there are several methods of maintenance therapy, one of the most widely used methods is designed to correct the deficiency of acetylcholine. In the search for new potential inhibitors of cholinesterase enzymes, eight new derivatives of 3-oxo- or 2,3-indolo-triterpenic acid conjugated with amino-quinuclidine bicyclic cores were designed and synthesized.

The burden of headache disorders among medical students in Vietnam: estimates from a cross-sectional study with a health-care needs assessment.

Background: In our previous study, we demonstrated that headaches are highly prevalent among medical students in Vietnam. In the present study, we provide estimates of the associated symptom burden and impaired participation, utilizing these estimates to assess headache-related healthcare needs within this population.

Methods: The study followed the standardized methodology established by the Global Campaign against Headache.

Demonstration of adapted packed-bed bioreactor for accurate and rapid estimation of biochemical oxygen demand: insights into the influence of microbial community structure and functions.

This study demonstrated a novel approach to accurately estimate 5-day biochemical oxygen demand (BOD) in textile wastewater using a microbial consortium from food processing wastewater fixed on coconut fibers. Although glucose-glutamic acid (GGA) has been widely known as the most preferred substrates for microbial respiration, its calibration surprisingly resulted in an overestimation of BOD in textile wastewater due to its lower utilization rate compared to that of textile wastewater. After being adapted with a new nutrient environment composed of GGA and textile wastewater, the adapted packed-bed bioreactors (PBBRs) was capable of accurate estimation of BOD in textile wastewater using GGA standard solution.

In vitro Biological Evaluation and In silico Studies of a New Anthraquinone from Zingiber cassumunar Roxb. in Type 2 Diabetes Management.

A novel diphenyl-anthraquinone compound, cassuquinone A, was isolated from the rhizomes of Zingiber cassumunar. Structural elucidation was accomplished using detailed NMR and HRMS-ESI  techniques, revealing a symmetrical anthraquinone core with methoxylated aromatic rings. Cassuquinone A exhibited potent α-glucosidase inhibitory activity with an IC₅₀ of 11.