Publications by authors named "H O Yonas"
Article Synopsis
- The evaluation methods for assessing the injured brain have progressed significantly since 1960, when Lundberg first introduced intracranial pressure (ICP) measurement.
- Building on this, later research examined cerebral blood flow (CBF) and critical cerebral perfusion pressure (CPP) to better understand brain autoregulation and its limitations, particularly when mean arterial pressure (MAP) decreases.
- Recent advancements such as induced pressure reactivity (iPRx) and continuous multimodal monitoring have improved the identification of optimal CPP for patients with traumatic brain injury, but challenges remain regarding understanding the mechanisms behind CBF autoregulation loss due to increased ICP.
Microvascular Shunts, Intracranial Pressure, and the Impact of Drag-Reducing Polymers.
Adv Exp Med Biol
October 2024
Article Synopsis
- Edwin M. Nemoto reflects on his 50 years with ISOTT, highlighting the advancements in technologies like microelectrodes and near-infrared spectroscopy that have improved measurements of tissue oxygenation and metabolism.
- He cherishes the collaborations and scientific exchanges with notable researchers worldwide, considering these relationships as the most significant aspect of his experience.
- The text discusses the role of microvascular shunts in various organs that can worsen conditions like tissue injury and edema, describing how a specific drag-reducing polymer enhances blood flow and improves endothelial function by altering red blood cell dynamics.
The concept of hemodynamic compromise (HC) is used to detect brain regions under ischemic stress by impaired ability to dilate in response to a vasodilatory challenge for cerebrovascular reserve (CVR). The vasodilatory challenges are either inhaled CO or a carbonic anhydrase inhibitor acetazolamide (AZ) with measurements of cerebral blood flow (CBF) before and during the challenge. The rationale for CVR is that the brain under ischemic stress is vasodilated and the increase in CBF is attenuated.
View Article and Find Full Text PDFObjectives: To integrate morphological, haemodynamic and mechanical analysis of carotid atheroma driving plaque disruption.
Materials And Methods: First, we analysed the phenotypes of carotid endarterectomy specimens in a photographic dataset A, and matched them with the likelihood of preoperative stroke. Second, laser angioscopy was used to further define the phenotypes in intact specimens (dataset B) and benchmark with histology.
Background: Signaling pathways mediated by microRNAs (miRNAs) have been identified as one of the mechanisms that regulate stroke progression and recovery. Recent investigations using stroke patient blood and cerebrospinal fluid (CSF) demonstrated disease-specific alterations in miRNA expression. In this study, for the first time, we investigated miRNA expression signatures in freshly removed human stroke brain tissue.
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