Field-Based Evidence of Single and Few Doses of Annual Ivermectin Treatment Efficacy in Eliminating Skin Microfilaria Load after a Decade of Intervention.

Background: Impact assessment of community-based ivermectin treatment control of onchocerciasis is required to determine its effectiveness. This study was conducted to evaluate geographic coverage and demographic ivermectin treatment compliance.

Methods: The number of village dosage were obtained from the community based distributors.

Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria.

Baseline and impact assessment data were generated in 1994 (n = 532) and 2011 (n = 593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n = 445, 75%) were screened at both visits. Each village had received 11 (64.

Analysis of IgG isotype responses against Onchocerca volvulus antigens in children in an onchocerciasis-endemic area in northern Nigeria.

This study evaluated the usefulness of parasite-specific IgG and IgG isotype responses for diagnosing early or pre-patent onchocerciasis in children using sandwich ELISA. The children (n = 199) were aged between 5 and 12 years and living in a meso-endemic area of northern Nigeria. Only five had detectable skin microfilariae.

Effects of infection with Trypanosoma brucei brucei on different trimesters of pregnancy in ewes.

The effects of Trypanosoma brucei brucei infection during the first, second or third trimesters of pregnancy in 13 ewes were studied. All infected ewes were anaemic with the anaemia being most severe, moderate and least in ewes infected in the second, third and first trimesters, respectively. Weight loss occurred in all infected ewes but was most severe in ewes infected in the third trimester.