Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders.

The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified NB cells, Aurora kinase A (Aurora-A) binds to and stabilizes N-Myc, resulting in elevated protein levels. Here, we demonstrate that targeted protein degradation of Aurora-A decreases N-Myc levels.

Ensemble deep learning and EfficientNet for accurate diagnosis of diabetic retinopathy.

Diabetic Retinopathy (DR) stands as a significant global cause of vision impairment, underscoring the critical importance of early detection in mitigating its impact. Addressing this challenge head-on, this study introduces an innovative deep learning framework tailored for DR diagnosis. The proposed framework utilizes the EfficientNetB0 architecture to classify diabetic retinopathy severity levels from retinal images.

Dietary phytochemicals alleviate the premature skin aging: A comprehensive review.

Skin aging, often called as premature skin aging, is the hastened deterioration of the skin resulting from multiple factors, including UV radiation, environmental contaminants, inadequate nutrition, stress, etc. Dietary phytochemicals, present in fruits, vegetables, and other plant-derived meals, have gained interest due to their efficiency to eradicate free radicals and lowering the release of inflammatory mediators which accounts for premature skin aging. Several dietary phytochemicals, i.

Insights of Zinc Ion Storage in Chilli-Stem Derived Porous Carbon Enabling Ultrastability and High Energy Density of Zinc-Ion Hybrid Supercapacitors.

Aqueous zinc ion hybrid supercapacitors (ZIHSCs) are promising as low-cost and safe energy storage devices for next-generation applications. Still, their energy-power performance and durability are far from satisfactory. Here, we present an energy-dense, and ultrastable ZIHSC realized using activated porous carbons derived from chilli-stems.