Publications by authors named "H Nowotny"
Background: High dietary sodium intake is a major cardiovascular risk factor and adversely affects blood pressure control. Patients with primary aldosteronism (PA) are at increased cardiovascular risk, even after medical treatment, and high dietary sodium intake is common in these patients. Here, we analyze the impact of a moderate dietary sodium restriction on microbiome composition and immunophenotype in patients with PA.
View Article and Find Full Text PDFObjective: To study pregnancy outcomes and complications in women with congenital adrenal hyperplasia (CAH).
Methods: A retrospective multicenter study was conducted at tertiary reference centers in 5 countries (Austria, Germany, Italy, Sweden, USA), including 72 adult women with CAH (nonclassic [NC] n = 34, simple virilizing [SV] n = 21, salt wasting [SW] n = 17).
Results: A total of 133 pregnancies, 112 live births, and 25 abortions were documented.
Prenatal and Pregnancy Management of Congenital Adrenal Hyperplasia.
Clin Endocrinol (Oxf)
October 2024
Article Synopsis
- Patients with congenital adrenal hyperplasia (CAH) face fertility challenges due to hormonal imbalances, with women experiencing menstrual irregularities and reduced fertility linked to surgeries and hormonal therapy, particularly in classic CAH cases.
- Men with CAH may deal with fertility issues from conditions like hypogonadotrophic hypogonadism, but proper hormone treatment can potentially restore sperm production.
- Ethical concerns arise with prenatal treatments like dexamethasone in female fetuses to prevent virilization, highlighting the need for ongoing research, as seen in the international "PREDICT" study focused on effective prenatal CAH treatments.
Prevalence of adrenal rest tumors and course of gonadal dysfunction in a clinical sample of men with congenital adrenal hyperplasia: a longitudinal analysis over 10 years.
Eur J Endocrinol
August 2024
Article Synopsis
- Subfertility is common in men with classic 21-hydroxylase deficiency (21OHD), and a study tracked the long-term gonadal function of 27 men over a median of 12 years.
- testosterone levels were found to be below the normal range for a significant number of participants, with those having testicular adrenal rest tissue (TART) showing initially higher testosterone levels and a greater increase over time compared to those without TART.
- The results indicate that while testosterone levels are generally low in these men, they do not change much over time; hence, regular screening for TART isn't recommended, but monitoring Sertoli cell function is suggested for men with larger TART.
Hyperandrogenemia in patients with Cushing's syndrome (CS) presents a diagnostic pitfall due to its rare occurrence and overlapping symptoms with more common conditions like polycystic ovary syndrome (PCOS). This review explores the significance of androgen dysregulation in CS, focusing on both classical and 11-oxygenated androgens. While classical androgens contribute to hyperandrogenism in CS, their levels alone do not fully account for clinical symptoms.
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