Publications by authors named "H Nordstrom"
Article Synopsis
- ST131 E. coli is a globally recognized strain that causes hard-to-treat, multidrug-resistant infections due to its production of extended-spectrum β-lactamases (ESBLs).
- Researchers sequenced the genomes of 154 clinical isolates from the ST131 lineage at the University of Pittsburgh Medical Center and found that clade C predominated, comprising 89% of the samples.
- Analysis revealed genes under selection in clade C and highlighted the diversity of ESBL-encoding genes and mobile elements, indicating ongoing adaptation in this strain.
Purpose: Dose painting radiation therapy delivers a nonuniform dose to tumors to account for heterogeneous radiosensitivity. With recent and ongoing development of Gamma Knife machines making large-volume brain tumor treatments more practical, it is increasingly feasible to deliver dose painting treatments. The increased prescription complexity means automated treatment planning is greatly beneficial, and the impact of dose painting on stereotactic radiosurgery (SRS) plan quality has not yet been studied.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on a new method to non-invasively assess fibrogenic activity, which could enhance the treatment of fibrotic diseases and aid in developing anti-fibrotic medications.
- Researchers explored a specific Affibody molecule (Z09591) labeled using the RESCA method to create a tracer for detecting fibrogenic cells without invasive procedures.
- In experiments with tumor-bearing mice, the resulting radiotracer showed high selectivity for a key receptor associated with fibrosis, demonstrating its potential for accurate monitoring of liver fibrogenesis and implications for drug development.
Background: Dynamic treatment in Gamma Knife (GK) radiosurgery systems delivers radiation continuously with couch movement, as opposed to stationary step-and-shoot treatment where radiation is paused when moving between isocenters. Previous studies have shown the potential for dynamic GK treatment to give faster treatment times and improved dose conformity and homogeneity. However, these studies focused only on computational simulations and lack physical validation.
View Article and Find Full Text PDFArticle Synopsis
- Many species of bacteria are resistant to antibiotics, creating challenges in treating infections caused by them.
- Bacteriophage therapy, which uses viruses that infect bacteria, may be a potential solution, but finding specific phages can be challenging.
- The study found that prophages within bacterial genomes could be a source of effective phages, showing various lytic activities against different bacterial isolates, suggesting they might be beneficial for future phage therapy.