Publications by authors named "H Nodarse Cuni"
Interferon-lambda 3 and 4 Polymorphisms Increase Sustained Virological Responses and Regulate Innate Immunity in Antiviral Therapy With Pegylated Interferon-Alpha.
Andréa Marques Vieira da Silva Lucia Elena Alvarado-Arnez Tamiris Azamor Leonardo Ribeiro Batista-Silva Thyago Leal-Calvo Hugo Nodarse Cuni
Front Cell Infect Microbiol
July 2021
Article Synopsis
- The study investigates the role of host genetics, specifically single nucleotide polymorphisms (SNPs) in interferon lambda genes, in the immune response and treatment outcomes for chronic hepatitis C (CHC) patients.
- Three specific SNPs (rs12979860-CC, rs8109886-CC, and rs8099917-TT) were identified as predictive markers for sustained virologic response (SVR), with rs12979860-CC showing the strongest association.
- The research also highlighted the relationship between these genetic markers and cytokine levels, indicating a modulating effect on inflammation and immunity that could influence not only hepatitis C treatment but also other infections.
Background: Several countries have used pegylation technology to improve the pharmacokinetic properties of essential drugs. Recently, a novel interferon alfa-2b protein conjugated to four-branched 12 kDa polyethylene glycol molecules was developed jointly between Cuba and Brazil. The aim of this study was to compare the pharmacokinetic properties of BIP48 (pegylated interferon alfa-2b from Bio-Manguinhos/Fiocruz, Brazil) to those of PEGASYS® (commercially available pegylated interferon alfa-2a from Roche Pharmaceutical).
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