Publications by authors named "H Nishiba"
Renal function significantly influences the appropriate warfarin dosage. However, studies investigating the impact of genetic factors on warfarin dosage, considering renal function, are limited. This study aimed to assess the role of genetic polymorphisms in , , , , , and in warfarin dosage adjustment considering renal function.
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- Opioids, which are commonly used for pain relief, often cause constipation, particularly in older adults—this study focuses on a treatment for that issue called naldemedine for patients over 75 with cancer.* -
- The researchers analyzed medical records from 10 hospitals in Japan, studying 60 cancer patients who were hospitalized for at least a week before and after starting naldemedine.* -
- Results showed a 68.3% response rate in increasing bowel movements, with diarrhea being the most frequent side effect, mostly mild, indicating that naldemedine is both effective and safe for older cancer patients dealing with opioid-induced constipation.*
Article Synopsis
- * The study retrospectively tracked 33 patients with various gastrointestinal cancers in Japan who were treated with naldemedine, focusing on their defecation frequency before and after starting the medication.
- * Results showed a 63.6% response rate, with significant increases in bowel movements after naldemedine use; most patients reported minor gastrointestinal side effects, indicating that naldemedine is generally safe and effective for managing OIC in these cancer patients.
: Opioid analgesics, which are used for cancer-related pain management, cause opioid-induced constipation (OIC). Naldemedine, a peripheral opioid receptor antagonist, is an OIC-modifying agent, but no focused efficacy and safety analysis has been conducted for its use in hepatobiliary pancreatic cancers. We performed a multi-institutional study on the efficacy and safety of naldemedine in patients with hepatobiliary pancreatic cancer using opioids in clinical practice.
View Article and Find Full Text PDFConstipation is a concern among patients with Eastern Cooperative Oncology Group (ECOG) performance status (PS) of 3 and 4. To assess naldemedine's efficacy and safety in cancer patients on opioids with poor PS. Multicenter, retrospective study.
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