Hyperthyroidism and hypothyroidism in patients with autoimmune pancreatitis.

Objective: The objective of this study is to clarify the clinical features of thyroid dysfunction observed in patients with autoimmune pancreatitis (AIP).

Methods: We repeatedly examined thyroid function in 74 patients with type 1 AIP (58 males, 16 females; average onset age of AIP 67 years). Clinical and serological findings in patients with thyroid dysfunction were analyzed.

Hepatoid adenocarcinoma of the stomach: a case report.

A patient with primary gastric carcinoma showing a high level of serum a-fetoprotein (AFP) (368 ng/ml) is described. Subtotal gastrectomy was performed, and a month after surgery the level of serum AFP fell rapidly to within normal limits. Histologically, two types of cells coexisted in the tumor: medullary-type cells resembling trabecular-type hepatocellular carcinoma, and moderately differentiated adenocarcinoma cells.

Localization of sulfatides in the epithelial lining of gastric mucosa: studies with a monoclonal antibody to sulfatides.

A specific monoclonal antibody against sulfatides was used to examine the cellular localization of sulfatides, the most predominant acidic glycosphingolipids in both rabbit and human gastric mucosa. The monoclonal antibody selectively recognized sulfatides among the acidic glycolipids extracted from rabbit gastric mucosa. Immunofluorescence staining revealed that specific staining was localized in the epithelial cells of the stomach.

Systematic analysis of glycosphingolipids in the human gastrointestinal tract: enrichment of sulfatides with hydroxylated longer-chain fatty acids in the gastric and duodenal mucosa.

The composition of the glycosphingolipids of the human gastrointestinal tract was studied. The major neutral glycosphingolipids were ceramide monohexosides (e.g.