Publications by authors named "H Narahara"
Article Synopsis
- Soft tissue sarcomas (STSs) are rare cancers with poor prognosis, especially at advanced stages, and treatment options, such as chemotherapy with eribulin, are limited for most subtypes.
- A nationwide study in Japan assessed eribulin's real-world effectiveness and safety in patients with various STS types, enrolling 256 patients and focusing on overall survival and other clinical outcomes.
- The results showed median overall survival of 10.8 months for all patients, with lower survival for non-L-type sarcomas; eribulin had an objective response rate of 8.1% and a disease control rate of 42.6%, with a significant portion of patients experiencing adverse drug reactions.
It is very important to investigate the expression of endometrial receptive markers in the endometrium during implantation. Therefore, we examined whether it would be possible to analyze endometrial receptivity using cells from embryo transfer catheters. A total of 81 cycles from 81 consenting patients were enrolled in this study.
View Article and Find Full Text PDFIt is suggested that aberrantly expressed microRNAs are involved in the pathogenesis of endometriosis. Our previous study demonstrated that expression of the microRNA hsa-miR-199a-3p is attenuated in human endometriotic cyst stromal cells (ECSCs). The current study aimed to define the roles of hsa-miR-199a-3p in the development of endometriosis.
View Article and Find Full Text PDFDNA replication inhibitors are utilized extensively in studies of molecular biology and as chemotherapy agents in clinical settings. The inhibition of DNA replication often triggers double-stranded DNA breaks (DSBs) at stalled DNA replication sites, resulting in cytotoxicity. In East Asia, some traditional medicines are administered as anticancer drugs, although the mechanisms underlying their pharmacological effects are not entirely understood.
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