Publications by authors named "H Nagashima"
Article Synopsis
- Memory-phenotype (MP) CD4 T lymphocytes develop from naïve T cells and can differentiate into various T cell subsets to manage inflammation, especially in low-immune settings.
- The study highlights that MP lymphocytes are not only made up of T helper 1 (T1) and T helper 17 (T17) cells but also contain a "undifferentiated" subpopulation that has the potential to develop into these functional subsets.
- The undifferentiated MP lymphocytes possess the ability to proliferate rapidly and can differentiate into T1, T17, and regulatory T cells, which contributes to inflammation, although their response is regulated by existing T cells.
The type 2 cytokines, interleukin (IL)-4, IL-13 and IL-5 reside within a multigene cluster. Both innate (ILC2) and adaptive T helper 2 (T2) lymphocytes secrete type 2 cytokines with diverse production spectra. Using transcription factor footprint and chromatin accessibility, we systemically cataloged regulatory elements (REs) denoted as SHS-I/II, KHS-I/II, +6.
View Article and Find Full Text PDFPossible existence of dose-rate threshold for mutation induction by chronic low-dose-rate gamma-rays.
Radiat Prot Dosimetry
November 2024
To assess the biological effects of low-dose and low-dose-rate radiation, we established a sensitive assay system for detecting somatic mutations in hypoxanthine-phosphoribosyltransferase 1 (HPRT1) gene. In this study, we investigated the dose-rate effects of mutagenesis by gamma irradiation at dose-rates of 6.6, 20 and 200 mGy d-1.
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