Clinical and demographic factors affecting trough levels of isavuconazole in critically ill patients with or without COVID-19.

Background: The broad-spectrum antifungal isavuconazole is administered to treat invasive aspergillosis and mucormycosis.

Objectives: Isavuconazole plasma concentrations in critically ill ICU patients with or without COVID-19 and invasive fungal infection were determined, and factors for sub-therapeutic drug levels (<1 μg/mL) were evaluated.

Patients And Methods: Isavuconazole plasma levels were measured as part of therapeutic drug monitoring (TDM) in ICUs of a tertiary hospital.

Stable isotopes provide evidence that condensed tannins from sericea lespedeza are degraded by ruminal microbes.

The objective of Trial 1 was to determine the effects of condensed tannins (CT) from sericea lespedeza [SL; Lespedeza cuneata (Dum. Cours.) G.

Inclusion of a tannin-rich legume in the diet of beef steers reduces greenhouse gas emissions from their excreta.

The objectives of this study were to determine the emission of nitrous oxide (NO), methane (CH), and carbon dioxide (CO), as well as the isotopic composition of NO from excreta of beef steers fed 'AU Grazer' sericea lespedeza hay [SL; Lespedeza cuneata (Dum. Cours.) G.

Isavuconazole therapeutic drug monitoring in critically ill ICU patients: A monocentric retrospective analysis.

Background: The broad-spectrum triazole isavuconazole is used for the treatment of invasive aspergillosis and mucormycosis. Data regarding human plasma concentrations in clinical routine of the drug are rare.

Objectives: Plasma concentrations of isavuconazole were determined in critically ill ICU patients while considering different patients' characteristics.