GDC: Integration of Multi-Omic and Phenotypic Resources to Unravel the Genetic Pathogenesis of Hearing Loss.

Effective research and clinical application in audiology and hearing loss (HL) require the integration of diverse data, yet the absence of a dedicated database impedes understanding and insight extraction in HL. To address this, the Genetic Deafness Commons (GDC) is developed by consolidating extensive genetic and genomic data from 51 public databases and the Chinese Deafness Genetics Consortium. This repository comprises 5 983 613 variants across 201 HL genes, revealing the genetic landscape of HL and identifying six novel mutational hotspots within the DNA-binding domains of transcription factors.

The comparative efficacy of L-glutamine, celecoxib, and glucosamine sulfate in osteoarthritis management.

To explore the therapeutic efficacy of L-glutamine (L-Gln) on pathological progression and clinical symptoms of osteoarthritis (OA), and compare with glucosamine sulfate (GS), and celecoxib (CXB). Rats were administered sodium chloride, L-Gln, GS, or CXB via gavage for eight weeks starting from the fifth week after sham operation or Anterior Cruciate Ligament Transection (ACLT) + Medial Meniscectomy (MMx). Then the severity of knee OA in rats was evaluated by serological analysis, histological examination and imaging examination.

Root-zone oxygen supply mitigates waterlogging stress in tomato by enhancing root growth, photosynthetic performance, and antioxidant capacity.

Water-air coupled oxygen supply to the root zone can significantly enhance crop yield and quality under non-waterlogged conditions. However, its impact on crops subjected to waterlogging-induced hypoxia remains unclear. In this study, tomatoes were chosen as the model crop due to their economic value and sensitivity to waterlogged conditions.

Lymphocyte/monocyte to lactate dehydrogenase ratio prior to lymphodepletion impact the outcomes of patients with diffused large B cell lymphoma undergoing CAR-T cell therapy.

Factors associated with outcomes of chimeric antigen receptor (CAR)-T cell therapy in patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have not been fully elucidated. We explored the impact of the prelymphodepletion (pre-LD) lymphocyte to monocyte ratio (LMR) and its ratio to lactate dehydrogenase (LDH) (LMR/LDH) on the efficacy and prognosis of 60 patients with R/R DLBCL undergoing CAR-T cell therapy. The optimal cutoff values for pre-LD LMR and LMR/LDH were 3.

Identification and characterization of Fusarium acuminatum causing root rot on sesame in Noutheast of China.

Background: Sesame is an important oil-producing crop, possessing approximately 50% oil and 20% protein content, along with a variety of antioxidant substances, endowing it with high edible and medicinal value. However, fungal diseases, especially Fusarium wilt with a high incidence, pose a significant threat and severely limit the development of the sesame industry.

Methods And Results: In this study, we identified symptoms of sesame fusarium wilt as with the midrib as the boundary, half of the leaf turns yellow while the other half remains normal, plantwilted and rotting roots, and eventually plant wilting and death.