Publications by authors named "H Mziaut"
Article Synopsis
- - Primary cilia in pancreatic beta cells are crucial for paracrine signaling, and their dysfunction is linked to diabetes, but their structural functions are not well understood.
- - Researchers used electron and expansion microscopy to create 3D models of these cilia, revealing they are confined in deep pockets, lack movement components, and have an unstructured organization.
- - The study identified unique interactions between beta cell cilia and other cells, including specialized connections to cholinergic nerves, emphasizing the importance of cilia in integrating signals that affect islet function in relation to health and diabetes.
Objective: MicroRNAs (miRNAs) play an integral role in maintaining beta cell function and identity. Deciphering their targets and precise role, however, remains challenging. In this study, we aimed to identify miRNAs and their downstream targets involved in the regeneration of islet beta cells following partial pancreatectomy in mice.
View Article and Find Full Text PDFAims/hypothesis: Pancreatic islet beta cell failure causes type 2 diabetes in humans. To identify transcriptomic changes in type 2 diabetic islets, the Innovative Medicines Initiative for Diabetes: Improving beta-cell function and identification of diagnostic biomarkers for treatment monitoring in Diabetes (IMIDIA) consortium ( www.imidia.
View Article and Find Full Text PDFInsulin secretory granule (SG) turnover consists of several highly regulated processes allowing for proper β-cell function and insulin secretion. Besides the spatial distribution of insulin SGs, their age has great impact on the likelihood of their secretion and their behaviour within the β-cell. While quantitative measurements performed decades ago demonstrated the preferential secretion of young insulin, new experimental approaches aim to investigate insulin ageing at the granular level.
View Article and Find Full Text PDFObjective: Insulin release from pancreatic islet β cells should be tightly controlled to avoid hypoglycemia and insulin resistance. The cortical actin cytoskeleton is a gate for regulated exocytosis of insulin secretory granules (SGs) by restricting their mobility and access to the plasma membrane. Prior studies suggest that SGs interact with F-actin through their transmembrane cargo islet cell autoantigen 512 (Ica512) (also known as islet antigen 2/Ptprn).
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