Controlled to uncontrolled drug use: The impact of Covid-19 among young people in the UK.

The Covid-19 pandemic lockdown had a profound impact on British young adults' drug using lives. Overnight, participants found themselves unable to access the protective mechanisms, specifically peer groups and routines on which they had come to rely to control and maintain pleasure with their drug use. The resulting analysis from online semi-structured qualitative interviews with 14 young people exposes a trend in drug use patterns.

Targeted protein degradation with bifunctional molecules as a novel therapeutic modality for Alzheimer's disease & beyond.

Alzheimer's disease (AD) is associated with memory and cognitive impairment caused by progressive degeneration of neurons. The events leading to neuronal death are associated with the accumulation of aggregating proteins in neurons and glia of the affected brain regions, in particular extracellular deposition of amyloid plaques and intracellular formation of tau neurofibrillary tangles. Moreover, the accumulation of pathological tau proteoforms in the brain concurring with disease progression is a key feature of multiple neurodegenerative diseases, called tauopathies, like frontotemporal dementia (FTD) where autosomal dominant mutations in the tau encoding MAPT gene provide clear evidence of a causal role for tau dysfunction.