Publications by authors named "H Mueller"
Article Synopsis
- - The study explored the risk factors and consequences of acute exacerbations in patients with progressive fibrosing interstitial lung diseases (ILDs), using data from the INBUILD trial, which involved treatments with nintedanib versus placebo.
- - Results showed that 8.7% of patients experienced acute exacerbations, with lower lung function and older age being significant risk factors, while nintedanib treatment seemed to reduce the risk of these events.
- - The analysis indicated that acute exacerbations are linked to high mortality rates, with approximately 19% of patients at risk of death within 30 days following such events.
Apoferritin (apoF) is commonly used as a test specimen in single-particle electron cryo-microscopy (cryo-EM), since it consistently produces density maps that go to 3 Å resolution or higher. When we imaged apoF with a laser phase plate (LPP), however, we observed more severe particle-to-particle variation in the images than we had previously thought to exist. Similarly, we found that images of ribulose bisphosphate carboxylase/oxygenase (rubisco) also exhibited a much greater amount of heterogeneity than expected.
View Article and Find Full Text PDFDate palm (Phoenix dactylifera L.) is an important crop in arid regions and it is well adapted to desert ecosystems. To understand its remarkable ability to grow and yield in water-limited environments, we conducted experiments in which water was withheld for up to 4 weeks.
View Article and Find Full Text PDFArticle Synopsis
- MicroRNAs (miRNAs) play a key role in brain development but their regulatory networks are not well understood, prompting researchers to study them in mouse embryonic cortex at various stages.
- Through small RNA sequencing, specific clusters of co-regulated miRNAs were identified, with certain miRNAs acting as central players during early and late neurogenesis.
- The research also revealed that combinations of miRNAs can enhance gene silencing, providing insights into how miRNA networks influence factors essential for neuronal differentiation and overall brain development.