Publications by authors named "H Moulton"
Article Synopsis
- The zoonotic transmission of influenza A viruses (IAVs) and coronaviruses (CoVs) can lead to severe diseases, and the cleavage of glycoproteins is essential for their infectivity.
- The study focused on the role of transmembrane serine protease 2 (TMPRSS2) in cleaving viral proteins in human airway cells and its dependency for different IAV and CoV strains.
- Results showed that while TMPRSS2 is crucial for the activation of certain viruses like H1N1/1918 and MERS-CoV, others like SARS-CoV and some IAV subtypes show less dependency, indicating the potential for alternative proteases and highlighting TMPRSS2 as
Functional Neurological Disorder in Pediatrics: Diagnostic Considerations.
R I Med J (2013)
November 2024
Article Synopsis
- Functional neurological disorder (FND) is frequently diagnosed in pediatric healthcare settings and presents with a variety of neuropsychiatric symptoms.* -
- The DSM-V marks a significant change by recognizing FND as a rule-in diagnosis rather than just a diagnosis of exclusion, focusing on specific symptom presentations.* -
- This article is the first in a six-part series that will cover diagnostic criteria, risks, and prognostic factors of FND, introducing a case study for further exploration in future articles.*
Article Synopsis
- Scientists are focused on creating new medicines to fight the virus that causes COVID-19, called SARS-CoV-2.
- They tested a special treatment called 5'END-2, which is good at stopping the virus from growing in lab cells and mice.
- The results showed that using 5'END-2 in mice helped reduce the virus in their lungs, suggesting it might be a promising way to treat COVID-19.
The transmembrane serine protease 2 (TMPRSS2) activates the outer structural proteins of a number of respiratory viruses including influenza A virus (IAV), parainfluenza viruses, and various coronaviruses for membrane fusion. Previous studies showed that TMPRSS2 interacts with the carboxypeptidase angiotensin-converting enzyme 2 (ACE2), a cell surface protein that serves as an entry receptor for some coronaviruses. Here, by using protease activity assays, we determine that ACE2 increases the enzymatic activity of TMPRSS2 in a non-catalytic manner.
View Article and Find Full Text PDFInfluenza is a global health issue causing substantial health and economic burdens on affected populations. Routine, annual vaccination for influenza virus is recommended for all persons older than 6 months of age. The propagation of the influenza virus for vaccine production is predominantly through embryonated chicken eggs.
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