Publications by authors named "H Morovvati"
Microplastics are a common environmental pollutant that disrupts the reproductive system of living organisms. We investigated the reproductive toxicity of 2 μm polystyrene microplastics (PS-MPs) in mice and treated them with PS-MPs for 6 weeks. We demonstrated that PS-MPs decreased the gonadosomatic index and the serum concentration of pituitary-testicular axis hormones (Follicle-stimulating hormone, Luteinizing hormone, and testosterone).
View Article and Find Full Text PDFThe effect of chemotherapy for anti-glioblastoma is limited due to insufficient drug delivery across the blood-brain-barrier. Poloxamer 188-coated nanoparticles can enhance the delivery of nanoparticles across the blood-brain-barrier. This study presents the design, preparation, and evaluation of a combination of PLGA nanoparticles (PLGA NPs) loaded with methotrexate (P-MTX NPs) and PLGA nanoparticles loaded with paclitaxel (P-PTX NPs), both of which were surface-modified with poloxamer188.
View Article and Find Full Text PDFThe most common technique of orthopedic surgical procedure for the correction of deformities is bone lengthening by "distraction osteogenesis," which requires periodic and ongoing bone assessment following surgery. Bone impedance is a noninvasive, quantitative method of assessing bone fracture healing. The purpose of this study was to monitor bone healing and determine when fixation devices should be removed.
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- Enrofloxacin, a fluoroquinolone antibiotic, is investigated for its effects on growing lamb articular cartilage, due to its excessive use and potential skeletal impact.
- The study involved twelve male lambs, divided into control, therapeutic, and toxic groups, to examine changes in collagen content and gene expression related to cartilage health, specifically focusing on Sox9 and caspase-3.
- Findings indicated that enrofloxacin led to decreased matrix components and increased chondrocyte apoptosis, with more pronounced effects in the toxic group compared to the therapeutic group, raising concerns about its impact on cartilage development.
Introduction: The native inability of nervous system to regenerate, encourage researchers to consider neural tissue engineering as a potential treatment for spinal cord injuries. Considering the suitable characteristics of induced pluripotent stem cells (iPSCs) for tissue regeneration applications, in this study we investigated the adhesion, viability and proliferation of neural progenitors (derived from human iPSCs) on aligned poly-caprolactone (PCL) nanofibers.
Methods: Aligned poly-caprolactone nanofibrous scaffold was fabricated by electrospinning and characterized by scanning electron microscopy (SEM).