KB-0118, A novel BET bromodomain inhibitor, suppresses Th17-mediated inflammation in inflammatory bowel disease.

Inflammatory bowel disease (IBD) presents complex pathologies and remains challenging to treat, highlighting the urgent need for innovative therapeutics. This study evaluates KB-0118, a novel BET bromodomain inhibitor targeting BRD4, for its immunomodulatory effects in IBD. KB-0118 effectively inhibited pro-inflammatory cytokines, including TNF, IL-1β, and IL-23a, and selectively suppressed Th17 cell differentiation, a critical driver of IBD pathology.

An in-depth review on utilizing ultrasound biomicroscopy for assessing the iridocorneal angle and ciliary body in canines.

In this review, we explore the transformative role of Ultrasound Biomicroscopy (UBM) in veterinary ophthalmology, focusing on its utility in evaluating the iridocorneal angle and ciliary body in dogs. We begin by outlining UBM's foundational principles, providing a holistic understanding of its operational mechanics. This is followed by an exploration of the techniques and considerations for optimal UBM imaging, including the use of topical anesthesia, probe positioning, and maintaining a controlled measurement environment.

On-Site Identification of Corrosion Products and Evaluation of the Conservation Status of Copper Alloy Artworks Using a Portable Raman Spectrometer.

Copper alloys form various corrosion products such as sulfides and chlorides. Chlorides can cause severe structural damage in 'bronze disease', making the early identification of corrosion products and conservation treatment important tasks. In this study, standard spectra were established for nine minerals of corrosion products using a portable Raman spectrometer, and their identification was verified by comparing them with benchtop micro-Raman spectra.

Phase Change-Mediated Capture of Carbon Dioxide from Air with a Molecular Triamine Network Solid.

The efficient removal of CO from exhaust streams and even directly from air is necessary to forestall climate change, lending urgency to the search for new materials that can rapidly capture CO at high capacity. The recent discovery that diamine-appended metal-organic frameworks can exhibit cooperative CO uptake via the formation of ammonium carbamate chains begs the question of whether simple organic polyamine molecules could be designed to achieve a similar switch-like behavior with even higher separation capacities. Here, we present a solid molecular triamine, 1,3,5-tris(aminomethyl)benzene (TriH), that rapidly captures large quantities of CO upon exposure to humid air to form the porous, crystalline, ammonium carbamate network solid TriH(CO)·HO (TriHCO).