Wenckebach-periodic VA prolongation and abrupt shortening of HH interval during tachycardia indicate (i) a retrograde block at the upper common pathway that manifested a retrograde atrial activation via the superior slow pathway, and (ii) an antegrade return of a retrograde atrial activation to His bundle via the fast pathway.
View Article and Find Full Text PDFNew drug applications (NDAs) in Japan are reviewed by the Pharmaceuticals and Medical Devices Agency (PMDA). Those that pass the review are subsequently subject to deliberation by the Ministry of Health, Labour and Welfare Pharmaceutical Affairs and Food Sanitation Councils (MHLW-PAFSC), and the MHLW legislatively grants approval based on its positive opinions. However, little is known regarding the relationship between the PMDA review and the MHLW decision.
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