Publications by authors named "H Mitsui"
Activities on sandy soil are known to contribute to improved leg strength and balance. Lifesavers (LSs) have shown that sandy soil activity promotes intrinsic foot muscle development and improves balance. LS improves leg strength and balance through activities on sandy soil.
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- Generalized pustular psoriasis (GPP) is a serious skin condition characterized by recurrent, sterile pustules, primarily driven by the cytokine interleukin (IL)-36.
- A patient with a specific genetic variant did not respond adequately to treatment with spesolimab, which blocks IL-36 receptor signaling, as it helped reduce existing symptoms but failed to prevent new flare-ups.
- After noticing the resistance to spesolimab, bimekizumab, an antibody targeting IL-17A/IL-17F, was introduced and successfully resolved the patient's pustules and erythema, prompting a discussion on the underlying mechanisms of the resistance to spesolimab.
Deep burn injuries necessitate effective debridement to promote healing and reduce complications. Traditional surgical debridement is the standard of care; however, it can lead to significant tissue loss, excessive bleeding and delayed healing. Bromelain-based enzymatic debridement offers a potential less invasive alternative that aims to selectively remove necrotic tissue while preserving viable ones.
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- Atopic dermatitis (AD) is a chronic skin disease characterized by intense itching, and new treatments like dupilumab have been developed but predicting the right treatment for each patient is challenging.
- A study involving 110 AD patients aimed to identify factors and biomarkers that could indicate how well patients might respond to dupilumab, using various scales for assessment.
- Findings showed that higher baseline serum LDH levels and certain comorbidities, like food allergies, were linked to poorer treatment outcomes, suggesting these could help guide treatment decisions for AD patients.
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- Balance is crucial for elite lifesavers, and the study examines how dynamic balance relates to physical traits and functions.
- Researchers analyzed factors such as foot muscle area, ankle strength, toe grip strength, and foot sensation in 15 adult lifesavers (mostly male).
- Findings suggest that strong toe grip and ankle strength are key for maintaining balance on sand, and while sand training enhances these abilities, it might also reduce foot sensation if the intensity is too high—further research is needed.