Publications by authors named "H Minn"
The heart depends critically on continuous blood supply, but it is unknown whether cancer itself affects myocardial blood flow (MBF). This study investigated MBF in cancer patients and cardiac morphology in a cancer mice model. MBF was quantified with [O]HO positron emission tomography at rest in recently diagnosed breast cancer patients and age-matched female controls, and additionally during 10-min exercise in the cancer patients.
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- xCT (SLC7A11) is a protein involved in cell death regulation and antioxidant defense, and this study examined its impact on patients with head and neck squamous cell carcinoma (HNSCC).
- A total of 1,033 patients diagnosed between 2005-2015 were analyzed, with 585 having tumor samples for detailed immunohistochemical study, showing high follow-up rates.
- High levels of xCT expression significantly correlated with poorer 5-year survival rates in oropharyngeal squamous cell carcinoma (OPSCC) patients, indicating its potential as an important prognostic factor, especially for those receiving radiotherapy.
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- The study aimed to evaluate the effectiveness of simultaneous staining for p16 and p53 proteins in categorizing head and neck squamous cell carcinomas (HNSCC) as either HPV-associated or HPV-independent.
- Researchers stained 31 HNSCC samples for p16 and p53, and used advanced sequencing methods to analyze mutations and HPV presence in some cases.
- Results showed that most tumors (28 out of 31) could be classified simply based on the staining patterns, with most HPV-A tumors having p16 positivity and wildtype p53, while HPV-I tumors showed p16 negativity and abnormal p53 patterns.
Background: Mobilization of certain immune cells may improve the ability of the immune system to combat tumor cells, but the effect of acute exercise on mobilizing immune cells has been sparsely investigated in cancer patients. Therefore, we examined how acute exercise influences circulating immune cells in breast cancer patients.
Methods: Nineteen newly diagnosed breast cancer patients aged 36-68 performed 30 minutes of moderate-intensity exercise with a cycle ergometer.
In pre-clinical models of brain gliomas, Relaxation Along a Fictitious Field in second rotating frame (TRAFF2), continues wave T1rho (T1ρcw), adiabatic T1rho (T1ρadiab), and adiabatic T2rho (T2ρadiab) relaxation time mappings have demonstrated potential to non-invasively characterize brain gliomas. Our aim was to evaluate the feasibility and potential of 4 different spin lock methods at 3T to characterize primary brain glioma. 22 patients (26-72 years) with suspected primary glioma.
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