Ultrastructural analysis of mitochondrial morphology and in the human rhabdosphincter: Insights into urinary incontinence.

Urinary incontinence increases with age, reducing the elderly quality of life. Understanding its mechanisms and developing treatments are urgent tasks. While healthy striated muscle maintains homeostasis through mitophagy, aging is thought to reduce autophagy activity.

Small Renal Cell Carcinoma Presenting With Testicular Metastasis: A Rare Case of pT1a Disease With an Aggressive Clinical Course.

Testicular metastasis of a renal cell carcinoma (RCC) is extremely rare, particularly in the initial clinical presentation. Herein, we describe a unique case in which a small renal mass (pT1a RCC) initially manifested as a contralateral testicular metastasis. A 64-year-old man presented with a right intrascrotal mass.

Association Between Dietary Habit Changes and COVID-19 Prophylaxis During the Pandemic Among Japanese Maintenance Hemodialysis Patients.

Background: Following COVID-19, dietary habits have been altered frequently along with other societal lifestyle modifications. However, changes in the dietary habits of maintenance hemodialysis patients (MHPs) before and during COVID-19 have not been investigated.

Methods: A total of 132 MHPs were assessed for changes in their dietary habits before and during the pandemic and their association with COVID-19 prevention.

Differences in Clinical Outcomes and Survival Among Primary, Secondary, and Concomitant Carcinoma In Situ of the Bladder.

Purpose: Carcinoma in situ (CIS) is a flat, high-grade, and aggressive form of urothelial carcinoma with a high risk of progression to muscle-invasive disease and metastasis. This study aimed to investigate differences in clinical outcomes and survival among patients with primary, secondary, and concomitant CIS of the bladder.

Methods: A total of 209 patients diagnosed with CIS between 2010 and 2022 in our department with a minimum follow-up of 12 months were retrospectively analyzed.

Simple predictors for the completion of scheduled gemcitabine‑cisplatin regimens based on real‑world urothelial cancer data.

Gemcitabine plus cisplatin (GC) is the standard first line of chemotherapy for urothelial carcinoma. However, it is often difficult to complete scheduled GC therapy because of real-world adverse events. Therefore, the reasons behind delays, scheduled cancelations and determined predictive factors for completing scheduled GC therapy were retrospectively analyzed.