The efficacy of orally applied terbinafine, itraconazole and fluconazole in models of experimental trichophytoses.

The antimycotic efficacy of terbinafine, itraconazole and fluconazole was evaluated in guinea-pig trichophytoses (Trichophyton mentagrophytes, Trichophyton rubrum) by use of the hair root invasion test (HIT) and the auricular skin temperature test (STT). In the prophylactic HIT model using T. mentagrophytes as the infective agent, statistical evaluation of the ratios of protected/inoculated animals revealed ED50 values of 2.

Preclinical antimycotic activity of SDZ 89-485: a new orally and topically effective triazole.

SDZ 89-485 is a new orally and topically active triazole antifungal with efficacy superior to reference compounds in most animal infection models used for preclinical comparison of antifungals. The compound inhibits mycelial transformation of Candida albicans in vitro at MIC50 concentrations of 0.006 and 0.

Preclinical evaluation of terbinafine in vivo.

The fungicidal activity of terbinafine which has been demonstrated in vitro for several strains of dermatophyte, filamentous and dimorphic fungi, has been demonstrated in vivo in model systems for dermatophytoses. This activity is accompanied by a fast onset of action which leads to superior antifungal efficacy when compared with fungistatic drugs.

Activity of terbinafine in experimental fungal infections of laboratory animals.

The allylamine derivative terbinafine is the first antifungal agent with primary fungicidal properties against dermatophytes which acts systemically after oral application as well as locally after topical application. Comparative oral studies carried out with griseofulvin and ketoconazole in model infections such as guinea pig trichophytosis and microsporosis revealed terbinafine to be superior to the reference compounds both clinically and mycologically. An excellent antimycotic activity of terbinafine was also demonstrable after topical treatment of guinea pig dermatophytoses caused by Trichophyton mentagrophytes or Microsporum canis.