Publications by authors named "H Michael"
Article Synopsis
- Spondyloarthritis (SpA) is a common issue for patients with inflammatory bowel disease (IBD), and using specific screening tools could help identify it earlier and improve treatment.
- A study analyzed 669 IBD patients using two questionnaires (DETAIL and IBIS-Q) to check for SpA symptoms; many patients screened positive, with more showing axial symptoms rather than peripheral issues.
- The results highlighted that a significant number of patients with IBD might have undiagnosed SpA, particularly with the IBIS-Q being more effective in identifying potential cases, indicating a need for better rheumatology referrals for these patients.
Peritoneal dialysis (PD) is an increasingly needed, life-maintaining kidney replacement therapy; efficient solute transport is critical for patient outcome. While the role of peritoneal perfusion on solute transport in PD has been described, the role of cellular barriers is uncertain, the mesothelium has been considered irrelevant. We calculated peritoneal blood microvascular endothelial (BESA) to mesothelial surface area (MSA) ratio in human peritonea in health, chronic kidney disease, and on PD, and performed molecular transport related gene profiling and single molecule localization microscopy in two mesothelial (MC) and two endothelial cell lines (EC).
View Article and Find Full Text PDFGamma delta (γδ) T cells, which reside in mucosal and epithelial tissues, are integral to immune responses and are involved in various cancers, autoimmune, and infectious diseases. To study human γδ T cells to a translational level, we developed γδ humanized TCR-T1 (HuTCR-T1) mice using our TruHumanization platform. We compared the metabolomic profiles from plasma samples of wild-type (WT), γδ HuTCR-T1 mice, and humans using UHPLC-MS/MS.
View Article and Find Full Text PDFArticle Synopsis
- The study explores how levels of mature brain-derived neurotrophic factor (mBDNF) and its precursor, proBDNF, relate to cognitive function in HIV-positive adults in sub-Saharan Africa who haven't started antiretroviral therapy (ART).
- Increased mBDNF levels were positively associated with better cognitive performance, while higher proBDNF levels correlated with poorer cognitive outcomes, especially affecting fine motor skills.
- The research suggests that mBDNF and proBDNF play different roles in cognitive health for those with HIV, indicating a need for further studies to understand their impact during ART initiation and how they could guide neurocognitive interventions.
Objective: To systematically review the literature of existing evidence on the measurement properties of the Quality of Life in Neurological Disorders (Neuro-QoL) measurement system among neurorehabilitation populations.
Data Sources: The Consensus-based Standards for the selection of health Measurement Instruments (COSMIN) guided this systematic review in which we searched nine electronic databases and registries, and hand-searched reference lists of included articles.
Study Selection: Two independent reviewers screened selected articles and extracted data from 28 included studies.