Publications by authors named "H Merzouk"
Camel α-Lactalbumin (α-LAC) has been shown to exert bioactivities for Reactive oxygen species (ROS) scavenging and anti-inflammation, showing the ability to treat obesity-related metabolic disorders. Herein, we present a novel process to purify α-LAC in a single chromatographic step from camel whey in a flow-through format. We also demonstrate the role of α-LAC modulation strategies for the treatment of obesity.
View Article and Find Full Text PDFArticle Synopsis
- Diabetes mellitus causes significant organ damage due to oxidative stress, and traditional insulin therapies often do not fully address this issue.
- This study tested a new oral nanoparticle-mediated insulin (nCOF/Insulin) in diabetic rats and compared its effectiveness to subcutaneous insulin.
- Results showed nCOF/Insulin not only improved blood glucose control but also reduced oxidative stress and organ damage, suggesting it could enhance the quality of life for diabetes patients.
Complications associated with Type 1 diabetes (T1D) have complex origins that revolve around chronic hyperglycemia; these complications involve hemostasis disorders, coagulopathies, and vascular damage. Our study aims to develop innovative approaches to minimize these complications and to compare the outcomes of the new approach with those of traditional methods. To achieve our objective, we designed novel nanoparticles comprising covalent organic frameworks (nCOF) loaded with insulin, termed nCOF/Insulin, and compared it to subcutaneous insulin to elucidate the influence of insulin delivery methods on various parameters, including bleeding time, coagulation factors, platelet counts, cortisol plasma levels, lipid profiles, and oxidative stress parameters.
View Article and Find Full Text PDFThe present study was carried out to valorize the (OFI) by-products by extracting and identifying their biochemical compounds and evaluating their antioxidant potential by in vitro activities (DPPH radical and FRAP), as well as their capacity to stabilize margarine oxidation (rancimat test). In addition, their in vitro anticoccidial effect on the destruction of oocysts isolated from naturally infected chickens was also targeted. Microwaves and response surface methodology tools were used to extract the maximum amount of phenolic compounds (42.
View Article and Find Full Text PDFBackground: The Algerian COVID-19 vaccination campaign, which started at the end of January 2021, is marked by a slowly ascending curve despite the deployed resources. To tackle the issue, we assessed the levels and explored determinants of engagement toward the COVID-19 vaccine among the Algerian population.
Methods: A nationwide, online-based cross-sectional study was conducted between March 27 and April 30, 2021.