Publications by authors named "H Mendez"
Background: Cachexia is defined by chronic loss of fat and muscle, is a frequent complication of pancreatic ductal adenocarcinoma (PDAC), and negatively impacts patient outcomes. Nutritional supplementation cannot fully reverse tissue wasting, and the mechanisms underlying this phenotype are unclear. This work aims to define the relative contributions of catabolism and anabolism to adipose wasting in PDAC-bearing mice.
View Article and Find Full Text PDFBackground: Binge alcohol drinking is a dangerous behavior that can contribute to the development of more severe alcohol use disorder. Importantly, the rate and severity of alcohol use disorder has historically differed between men and women, suggesting that there may be sex differences in the central mechanisms that modulate alcohol (ethanol) consumption. Corticotropin-releasing factor (CRF) is a centrally expressed neuropeptide that has been implicated in the modulation of binge-like ethanol intake, and emerging data highlight sex differences in CRF systems.
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- Trauma and pre-existing conditions (PECs) significantly influence the hospital and ICU length of stay (LOS) for older patients aged 55 and above, highlighting the need for focused care in this demographic.
- In a study of 5,168 trauma patients, certain PECs like congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and chronic renal failure (CRF) were found to increase H-LOS and ICU-LOS by several days.
- The findings suggest that recognizing and managing PECs in older trauma patients is crucial, as it can lead to more effective care and potentially shorter hospital stays.*
Tumor immune resistance is recognized as a contributor to low survivorship in pancreatic ductal adenocarcinoma (PDAC). We developed a novel murine model of spontaneous PDAC clearance, generated by overexpressing interleukin-6 (IL-6) in orthotopically implanted PDAC cancer cells (OT-PDAC). Circulating IL-6 was 100-fold higher in OT-PDAC than in OT-PDAC mice.
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- * The study identifies RNU4-2, a non-coding RNA gene, as a significant contributor to syndromic NDD, revealing a specific 18-base pair region with low variation that includes variants found in 115 individuals with NDD.
- * RNU4-2 is highly expressed in the developing brain, and its variants disrupt splicing processes, indicating that non-coding genes play a crucial role in rare disorders, potentially aiding in the diagnosis of thousands with NDD worldwide.