Publications by authors named "H Melhus"
Background: The effect of milk on the risk of ischemic heart disease (IHD) and acute myocardial infarction (MI) is unclear. We aimed to examine the association between non-fermented and fermented milk consumption on these endpoints and investigate the relationship between milk intake and cardiometabolic-related proteins in plasma.
Methods: Our study is based on two Swedish prospective cohort studies that included 59,998 women and 40,777 men without IHD or cancer at baseline who provided repeated measures of diet and lifestyle factors and plasma proteomics data in two subcohorts.
Article Synopsis
- - The study investigated the relationship between non-HDL cholesterol (non-HDL-C) levels after a myocardial infarction (MI) and the risk of negative cardiovascular outcomes using data from over 56,000 patients.
- - Findings showed that achieving low non-HDL-C levels (below 2.2 mmol/L) quickly and maintaining them over time significantly reduced the risk of major adverse cardiovascular events (MACE), including death and non-fatal MI.
- - The results suggest that early and sustained cholesterol management after MI may lead to better health outcomes, challenging traditional gradual approaches to cholesterol reduction that could delay reaching these important targets.
We aimed to estimate the absolute and age-standardized number of hip fractures in Sweden during the past two decades to produce time trends and future projections. We used nationwide register data from 1998 to 2019 and a validated algorithm to calculate the annual absolute and age-standardized number of incident hip fractures over time. The total hip fracture burden was 335,399 incident events over the 22 years, with a change from 16,180 in 1998 to 13,929 in 2019, a 14% decrease.
View Article and Find Full Text PDFBackground: The incidence of atherosclerotic cardiovascular disease increases with levels of low-density lipoprotein cholesterol (LDL-C). Yet, a paradox may exist where lower LDL-C levels at myocardial infarction (MI) are associated with poorer prognoses.
Objective: To assess the association between LDL-C levels at MI with risk factor burden and cause-specific outcomes.
Aim: The aims of this study were (1) to identify older patients' risk factors for drug-related readmissions and (2) to assess the preventability of older patients' drug-related revisits.
Methods: Post hoc analysis of a randomized clinical trial with patients aged ≥65 years at eight wards within four hospitals in Sweden. (1) The primary outcome was risk factors for drug-related readmission within 12 months post-discharge.