[DNA diagnostics in dementia].

- Thanks to next-generation sequencing several genes can be examined in one go. Since this method has been introduced, the possibilities for DNA diagnostics in patients with dementia have increased tremendously in recent years.- DNA diagnostics is indicated for patients with an Alzheimer's disease diagnosis before they are 60 years old, for all patients with frontotemporal dementia and for patients with a positive family history.

Age- and Tumor Subtype-Specific Breast Cancer Risk Estimates for CHEK2*1100delC Carriers.

Purpose: CHEK2*1100delC is a well-established breast cancer risk variant that is most prevalent in European populations; however, there are limited data on risk of breast cancer by age and tumor subtype, which limits its usefulness in breast cancer risk prediction. We aimed to generate tumor subtype- and age-specific risk estimates by using data from the Breast Cancer Association Consortium, including 44,777 patients with breast cancer and 42,997 controls from 33 studies genotyped for CHEK2*1100delC.

Patients And Methods: CHEK2*1100delC genotyping was mostly done by a custom Taqman assay.

Doping concentration of GaN nanowires determined by opto-electrical measurements.

The influence of n-doping on the electrical transport properties of GaN nanowires is investigated by photoconductivity measurements on wires with different diameters. The electrical transport in nanowires is extremely sensitive to the wire diameter because of the size dependent barrier for surface recombination. This effect is used to determine the doping level of the nanowires and to complete and consolidate our previously developed surface recombination model for GaN nanowires.

How close does an uncemented hip stem match the final rasp position?

During total hip arthroplasty the final clinical position of the cementless CLS stem (Centerpulse) is not always identical to the position of the final rasp with which a successful trial reduction was performed. Therefore, the rasp-stem correspondence of CLS system (Centerpulse) was investigated in a laboratory study and compared to the CBC-T system (Mathys). Both systems showed an average rasp-stem mismatch below 2 mm in three orthogonal directions.

Good outcome and restoration of lordosis after anterior lumbar interbody fusion with additional posterior fixation.

Study Design: Fifty-two patients with degenerative disc disease underwent single- or double-level anterior lumbar interbody fusion with SynCage and additional posterior fixation as treatment for degenerative disc disease and were prospectively followed for 4 years.

Objectives: To test the clinical performance of anterior lumbar interbody fusion with SynCage, with emphasis on the safety and efficacy of the surgical procedure and the ability to restore anatomy and fuse the motion segment.

Summary Of Background Data: Anterior lumbar interbody fusion using femoral allograft and/or autologous bone has a high complication rate.