Comparative efficacy of HPV 16/18 DNA and E6/E7 mRNA testing in detecting high-grade cervical lesions (CIN2+) in women with cervical biopsies.

The study evaluated the efficacy of HPV 16/18 E6/E7 mRNA detection in women with abnormal cervical histology. A total of 99 cervical biopsy samples were analyzed, including 49 benign, 16 with cervical intraepithelial neoplasia grade 1 (CIN1), 9 with CIN2/3, and 25 with cervical cancers. Samples were tested for HPV 16/18 using both DNA and mRNA RT-PCR methods.

Novel Digital Anomalies, Hippocampal Atrophy, and Mutations Expand the Genotypic and Phenotypic Spectra of CNKSR2 in the Houge Type of X-Linked Syndromic Intellectual Development Disorder (MRXSHG).

The Houge type of X-linked syndromic intellectual developmental disorder (MRXSHG) encompasses a spectrum of neurodevelopmental disorders characterized by intellectual disability (ID), language/speech delay, attention issues, and epilepsy. These conditions arise from hemizygous or heterozygous deletions, along with point mutations, affecting CNKSR2, a gene located at Xp22.12.

Overexpression of PIN1 in patients with severe COVID-19.

This study aimed to investigate the significant expression of Peptidyl prolyl cis-trans isomerase (PIN1) as a key regulator of COVID-19 cycle. A quantitative real-time polymerase chain reaction (qRT-PCR) measured the expression levels of PIN1 in the serum of mild and severe patients and evaluated its association with clinical parameters. ROC curve analysis was performed to evaluate the expression of PIN1 for the diagnosis of COVID-19 between mild and severe patients.

Dataset from flexural, impact, and hydraulic pressure tests on driven energy piles.

Data from the flexural, impact, and hydraulic pressure tests performed on seven precast concrete driven energy piles is presented in this paper. The data is published and made publicly accessible through the open-access database DataverseNO. The dataset involves (a) material properties of all of the materials used in manufacturing the energy piles, (b) raw data files from impact tests, which are recorded by the pile driving analyzer (PDA) device and sensors, (c) the hydraulic pressure test data performed between the impact and bending tests, which includes the raw data of pressure measurements from analogue pressure gauge, and (d) the data from the bending tests which includes the raw and processed data files recorded by the displacement transducers, loadcell and also the raw and processed images for the digital image correlation (DIC) analysis.