Publications by authors named "H McParland"
Lichenoid morphology could be an early feature of oral proliferative verrucous leukoplakia.
J Oral Pathol Med
February 2021
Article Synopsis
- Recognition of early proliferative verrucous leukoplakia (PVL) can often be confused with other conditions like frictional keratosis and lichen planus, making accurate diagnosis challenging for clinicians.
- A study of 51 patients revealed that many had initial diagnoses that didn't indicate PVL; about 43% showed lichen planus features in their biopsies.
- Notably, 21.5% of the patients experienced malignant transformation during follow-up, indicating the importance of monitoring these cases closely for potential progression.
Background: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease predominantly affecting the oral mucosa. Optimal management relies upon thorough clinical assessment and documentation at each visit.
Objectives: The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in MMP.
The value of image cytometry DNA ploidy analysis and dysplasia grading to predict malignant transformation has been determined in oral lesions considered to be at 'high' risk on the basis of clinical information and biopsy result. 10-year follow up data for 259 sequential patients with oral lesions clinically at 'high' risk of malignant transformation were matched to cancer registry and local pathology database records of malignant outcomes, ploidy result and histological dysplasia grade. In multivariate analysis (n = 228 patients), 24 developed carcinoma and of these, 14 prior biopsy samples were aneuploid.
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