Publications by authors named "H McCann"
RNA secondary (2D) structure visualisation is an essential tool for understanding RNA function. R2DT is a software package designed to visualise RNA 2D structures in consistent, recognisable, and reproducible layouts. The latest release, R2DT 2.
View Article and Find Full Text PDFRecent advances in the field of translational chemical biology use diverse "proximity-inducing" synthetic modalities to elicit new modes of "event driven" pharmacology. These include mechanisms of targeted protein degradation and immune clearance of pathogenic cells. Heterobifunctional "chimeric" compounds like Proteolysis TArgeting Chimeras (PROTACs) and Antibody Recruiting Molecules (ARMs) leverage these mechanisms, respectively.
View Article and Find Full Text PDFRiboVision2 is a web server designed to visualize phylogenetic, structural, and evolutionary properties of ribosomal RNAs simultaneously at the levels of primary, secondary, and three-dimensional structure and in the context of full ribosomal complexes. RiboVision2 instantly computes and displays a broad variety of data; it has no login requirements, is open-source, free for all users, and available at https://ribovision2.chemistry.
View Article and Find Full Text PDFEvolving Archetypes: Learning from Pathogen Emergence on a Nonmodel Host.
Annu Rev Phytopathol
September 2024
Article Synopsis
- - Research focused on disease outbreaks enhances our knowledge of how microbes evolve and develop resistance, particularly in plant-pathogen interactions.
- - The emergence of Pseudomonas syringae pv. actinidiae (Psa) in kiwifruit illustrated rapid adaptation in hosts and resistance mechanisms influenced by mobile genetic elements.
- - Discoveries from the Psa3 pandemic have shed light on virulence factors and resistance gene evolution, revealing parallels in resistance mechanisms and the expansion of specific gene families in recently domesticated species.
Background: A rapid large-scale evaluation of a newly available duckbill style P2/N95 respirator, the Care Essentials (CE) MSK-003, was required to determine its suitability for deployment into the Victorian healthcare service. The aims of this study were to assess the feasibility of establishing a rapid, multi-organisational and multi-modal evaluation of the respirator, and to investigate whether this respirator would meet the needs of healthcare workers.
Methods: The evaluation was a collaboration among three healthcare organisations - two tertiary hospitals in metropolitan Melbourne and a rural-based hospital.