Prototype Analysis in Hopfield Networks With Hebbian Learning.

We discuss prototype formation in the Hopfield network. Typically, Hebbian learning with highly correlated states leads to degraded memory performance. We show that this type of learning can lead to prototype formation, where unlearned states emerge as representatives of large correlated subsets of states, alleviating capacity woes.

Synaptic gene expression changes in frontotemporal dementia due to the MAPT 10 + 16 mutation.

Aims: Mutations in the MAPT gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer's disease, the most common tauopathy, synapse loss is the strongest pathological correlate of cognitive decline. Recently, Positron Emission Tomography (PET) imaging with synaptic tracers revealed clinically relevant loss of synapses in primary tauopathies; however, the molecular mechanisms leading to synapse degeneration in primary tauopathies remain largely unknown.

Synaptic gene expression changes in frontotemporal dementia due to the 10+16 mutation.

Mutations in the gene encoding tau protein can cause autosomal dominant neurodegenerative tauopathies including frontotemporal dementia (often with Parkinsonism). In Alzheimer's disease, the most common tauopathy, synapse loss is the strongest pathological correlate of cognitive decline. Recently, PET imaging with synaptic tracers revealed clinically relevant loss of synapses in primary tauopathies; however, the molecular mechanisms leading to synapse degeneration in primary tauopathies remain largely unknown.

Fijian school students' Fiji English speech sound acquisition.

The aim of this study was to investigate Fijian students' acquisition of Fiji English speech sounds. Participants were 72 multilingual students (5-10 years) living in Fiji who spoke the Fijian or Fiji Hindi dialects of Fiji English. The students' productions of single words from the Diagnostic Evaluation of Articulation and Phonology (DEAP) were analysed according to dialect using the Children's Independent and Relational Phonological Analysis (CHIRPA).