Publications by authors named "H Matthaei"

The rapid development of minimally invasive surgery (MIS) and robot-assisted surgery (RAS) requires standardized training to ensure high-quality patient care. In Germany, there is currently a lack of a standardized curriculum that teaches these specialized skills. The aim of this study is to find a consensus for the development of a nationwide curriculum for MIS and RAS with the subsequent implementation of the consented content.

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Biliary tract cancers (BTC) are rare lethal malignancies arising along the biliary tree. Unfortunately, effective therapeutics are lacking and the prognosis remains dismal even for patients eligible for surgical resection. Therefore, novel therapeutic approaches along with early detection strategies and prognostic markers are urgently needed.

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Lenvatinib is a multiple receptor tyrosine kinase inhibitor (TKI) approved for first-line treatment of patients with unresectable hepatocellular carcinoma (HCC). TKI are suspected of exacerbating muscle loss in patients with cancer. In this study, we analyze the role of muscle loss in patients with advanced HCC treated with lenvatinib.

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Article Synopsis
  • A study analyzed 69 pancreatic intraductal papillary neoplasms (IPNs) and various related samples, identifying over 10,000 proteins and 22,000 glycopeptides using mass spectrometry.
  • *Among these, 756 proteins showed increased abundance in IPNs compared to normal pancreatic ducts, with 45% also found in cyst fluids.
  • *The research also distinguished two subtypes of IPMs and highlighted potential targets for earlier detection and treatment of pancreatic cancer.*
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Article Synopsis
  • - The study developed the LC-CVS OPSA, an assessment tool that focuses on safety in laparoscopic cholecystectomy surgery, to improve surgical training and align with the American Board of Surgery's initiatives.
  • - Expert surgeons rated ten surgical videos on a "safe" vs. "unsafe" scale, identifying 238 unsafe instances across various tasks and noting significant variations in ratings among the surgeons.
  • - Analysis of feedback revealed key reasons for unsafe ratings, such as failure to achieve the critical view of safety, suboptimal techniques, and potential future complications, leading to modifications in assessment instructions to enhance reliability.
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