The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.

The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes.

Successful Hepatectomy for a Liver Abscess With Portal Vein Thrombus and Hepatic Artery Dissection: A Case Report.

Liver abscesses can be associated with biliary disease and are occasionally accompanied by portal vein thrombosis. Hepatic artery obstruction has been reported to result from aneurysms, thrombosis, iatrogenic factors, and arterial dissection; however, to the best of our knowledge, no cases of liver abscess with obstruction of the portal vein and hepatic artery have been reported. A 51-year-old man presented with a chief complaint of heartburn.

Involvement of CaMKII in the modulation of I under oxidative stress in guinea pig sinoatrial node cells.

Our previous study found that Ca/calmodulin-dependent protein kinase II (CaMKII) potentiates the slow delayed rectifier K current (I) in sinoatrial node (SAN) pacemaker cells. Recently, oxidative activation of CaMKII has emerged as a major cause of SAN dysfunction; however, its correlation with I regulation remains unclear. In this study, we investigated the effect of hydrogen peroxide (HO) on I in SAN cells isolated from guinea pig heart.

High Antigenicity for T Cells Confers Resistance to PD-1 Blockade Therapy via High PD-1 Expression in T Cells.

Regulatory T (T) cells have an immunosuppressive function, and programmed death-1 (PD-1)-expressing T cells reportedly induce resistance to PD-1 blockade therapies through their reactivation. However, the effects of antigenicity on PD-1 expression in T cells and the resistance to PD-1 blockade therapy remain unclear. Here, we show that T cells gain high PD-1 expression through an antigen with high antigenicity.

The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2024.

The 2024 revised edition of the Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock (J-SSCG 2024) is published by the Japanese Society of Intensive Care Medicine and the Japanese Association for Acute Medicine. This is the fourth revision since the first edition was published in 2012. The purpose of the guidelines is to assist healthcare providers in making appropriate decisions in the treatment of sepsis and septic shock, leading to improved patient outcomes.