Novel function of Hox13 in regulating outgrowth of the newt hindlimb bud through interaction with Fgf10 and Tbx4.

5'Hox genes regulate pattern formation along the axes of the limb. Previously, we showed that Hoxa13/Hoxd13 double-mutant newts lacked all digits of the forelimbs during development and regeneration, showing that newt Hox13 is necessary for digit formation in development and regeneration. In addition, we found another unique phenotype.

Comprehensive analysis of peripheral blood free amino acids in MASLD: the impact of glycine-serine-threonine metabolism.

Little is known about how blood free amino acids (FAAs) change in metabolic dysfunction-associated steatotic liver disease (MASLD). This study aims to identify the imbalance of FAAs in MASLD and explore its correction as a potential therapeutic target. We analyzed plasma FAAs data from 23,036 individuals with steatosis information from a biobank in Japan, and 310 patients with MASLD were enrolled.

Candidate Toroidal Electric Dipole Mode in the Spherical Nucleus ^{58}Ni.

Dipole toroidal modes appear in many fields of physics. In nuclei, such a mode was predicted more than 50 years ago, but clear experimental evidence was lacking so far. Using a combination of high-resolution inelastic scattering experiments with photons, electrons, and protons, we identify for the first time candidates for toroidal dipole excitations in the nucleus ^{58}Ni and demonstrate that transverse electron scattering form factors represent a relevant experimental observable to prove their nature.

Thermodynamic Analysis of Mixed Adsorbed Film and Micelle Compositions above Critical Micelle Concentration.

In this paper, we proposed a thermodynamic procedure to evaluate binary surfactant mixed adsorbed film and mixed micelle compositions above critical micelle concentrations. This theory first calculates the change in the molar ratio of two surfactants in monomer and micelle states based on the phase-separation model and then imposes the chemical equilibrium between the mixed adsorbed film and mixed micelle of known composition and concentration. We applied this theory to a cationic-nonionic surfactant mixed system, and the relationship between the calculated mixed adsorbed film composition and foam film stability was discussed using the DLVO theory.

Development and Validation of Quality Indicators for Pulmonary Arterial Hypertension Management in Japan: A Modified Delphi Consensus Study.

Background: Quality indicators (QIs) are used to standardize care and improve outcomes in patients with pulmonary arterial hypertension (PAH). It is important that QIs are validated within specific healthcare contexts. Therefore, this study aimed to validate QIs for PAH management in Japan using a modified Delphi consensus method.